Author

Gu Xiao

City University of New YorkORCID 0000-0001-8433-9121Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Jill BargonettiiD· 2 shared Pamella LeybengrubiD· 2 shared Viola EllisoniD· 2 shared Alla Polotskaia· 1 shared Annmarie GaglioiD· 1 shared Benjamin D. GreenbaumiD· 1 shared Bo YaoiD· 1 shared Divya VenkateshiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Jill BargonettiORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJul 15, 2026

Spatial Topology Reveals Biologically Distinct Recurrent Motifs in Colorectal Cancer

Jia Yao, Yuqiu Yang, Y Jiang…·Y D Xie

The paper introduces STORM, a method to identify recurrent spatial motifs in colorectal cancer without cell-type labels, finding a fibroblast barrier linked to immune exclusion and prognosis.

DOI 10.64898/2026.07.09.737584

humanspatial transcriptomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 28, 2026

Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis

Gu Xiao, George K. Annor, Katherine W. Harmon…·Jill Bargonetti

This study shows mutant p53 uses its C-terminal domain to reprogram PARP activity, enabling replication stress adaptation and metastasis in TNBC, and identifies mtp53 as a biomarker for PARP inhibitor and DNA-damaging therapy.

DOI 10.64898/2026.03.26.713220

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyNucleic Acids ResearchPeer-reviewedJun 19, 2025

A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN

Viola Ellison, Alla Polotskaia, Gu Xiao…·Jill Bargonetti

This study identifies a cancer persistent DNA repair circuit involving mtp53, MDM2, and MDMX that recruits 53BP1 and MDC1 to chromatin, enhancing cell survival.

10 citations

humanproteomics

𝕏 PostBluesky