BiochemistryCommunications BiologyPeer-reviewed
Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity
Yuhan Jiang, Zhen Li, Dexin Sui…·Jian Ping Hu
This study rationally engineers ZIP8 to alter its substrate specificity, identifying a conditional selectivity filter that determines substrate preference based on transporter conformation.