ImmunologybioRxivPreprint
Structural basis of pro-inflammatory signaling via the Interleukin-36 receptor (IL-36R) mediated by IL-36γ and IL-37
Julie Andries, Martin Toul, Jan Félix…·Savvas N. Savvides
This study reveals the structural mechanisms of IL-36R activation by IL-36γ and IL-37 and spesolimab's allosteric antagonism, providing a blueprint for therapeutic targeting.
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