Scott Bottoms

This study engineers Saccharomyces cerevisiae to produce 3-hydroxypropionic acid and succinic acid from glucose-rich lignocellulosic wood hydrolysates under low pH conditions, increasing production titers significantly.

This study evaluates the use of fractionated hydrolysis lignin as a substrate for Pseudomonas putida and related strains to produce aromatic compounds, finding that filtered alkaline fractionation yields more catechol and is better for cis,cis-muconic acid production.

The paper introduces GRASP, a method for ancestral sequence reconstruction that handles large datasets and indels, demonstrating its ability to generate biologically active enzyme ancestors.