Indu Raman

This study shows that distributed clonal deletion checkpoints prevent autoimmune disease by restricting autoreactive B cell diversification and persistence.

This study identifies TDCA, a microbiota-derived bile acid, as a mediator that restores immune checkpoint therapy efficacy after antibiotic-induced hyporesponsiveness by enhancing CD8+ T cell antitumor immunity.

This study identifies biomechanical stiffening and fibrotic remodeling as hallmarks of early-onset colorectal cancer, showing their role in tumor initiation.

This study identifies distinct autoantibody profiles in tears and serum from NOD and NOR mice with Sjögren's disease-associated dacryoadenitis, highlighting tear IgA diversity and TLS as a potential source.

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

This paper develops pMTnet-omni, an AI system predicting TCR-pMHC binding across species and MHC classes, achieving high accuracy and showing clinical utility in predicting immune-related adverse events.