Author

Michael D. Hughes

Harvard UniversityORCID 0000-0001-8562-2316Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Davey M. SmithiD· 3 shared David Alain WohliD· 3 shared Eric S. DaariD· 3 shared Joseph J. EroniD· 3 shared Judith S. CurrieriD· 3 shared Kara W. ChewiD· 3 shared Alexander L. GreningeriD· 2 shared Amy HeapsiD· 2 shared

Activity by Year

2024-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Davey M. SmithORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologyJCI InsightPeer-reviewedDec 19, 2024

Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2

Sydney I. Ramirez, Paul G. Lopez, Farhoud Faraji…·ACTIV-2/A5401 Study Team

The paper examines early T cell and antibody responses in COVID-19 patients and finds they correlate with reduced SARS-CoV-2 viral RNA in the upper respiratory tract.

24 citationstop 2%

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyThe Journal of Infectious DiseasesPeer-reviewedJul 19, 2024

SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback

Nathaniel I. Bloom, Sydney I. Ramirez, Hallie Cohn…·Stacey Adams

This study shows that SARS-CoV-2 mAb treatment shifts memory B cell epitope recognition, affecting their response to vaccination.

18 citationstop 3%

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyPLoS PathogensPeer-reviewedApr 18, 2024

Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody

Tin Phan, Carolin Zitzmann, Kara W Chew…·the ACTIV-2/A5401 Study Team

This paper models viral resistance emergence in SARS-CoV-2 treated with anti-spike monoclonal antibodies, showing that target cell replenishment mechanisms can explain high viral rebounds.

24 citationstop 2%

humanstatistical model

𝕏 PostBluesky