Catherine D. Eichhorn

This study quantifies how Mg2+ modulates the conformational equilibrium of the 7SK RNA SL3 domain, showing a shift toward the SL3e state and identifying a DMS reactivity signature for A*C wobble base pairs.

The paper evaluates 53 Pepper RNA variants to show that HBC530 binding affinity and fluorescence intensity are only modestly correlated, with distal structural elements influencing both and Mg2+ binding being strongly correlated with HBC530 binding thermodynamics.

This paper presents the structure and thermodynamic analysis of the extended RNA recognition motif in hnRNPR-like proteins, revealing a conserved tryptophan cage motif critical for folding and stability.

The paper integrates NMR spectroscopy and chemical probing to visualize a two-state conformational ensemble in stem-loop 3 of 7SK RNA, showing structural dynamics and state conservation across vertebrates.