Silke Oeljeklaus

The paper identifies PEX38 as a novel, essential peroxin in Euglenozoa, evolved from a remnant GET-pathway factor, and highlights its role in peroxisomal membrane protein targeting and potential as a therapeutic target.

This study quantifies the yeast peroxisomal proteome under different metabolic conditions, revealing significant changes in protein abundance related to metabolic functions.

The paper shows TbTim20 is critical for protein import under low membrane potential in trypanosomes lacking mitochondrial DNA.

This study identifies PEX39 as a cytosolic peroxin that facilitates PTS2-protein import by interacting with PEX7 and stabilizing its binding to cargo.

This paper identifies TAC53 as a novel component of the Tripartite Attachment Complex (TAC) in Trypanosoma brucei, revealing its tubular architecture and role in mitochondrial DNA segregation.

The paper compares transcriptomics and proteomics data from wild-type and peroxisome-deficient yeast to identify changes in cellular processes due to peroxisome loss.

The paper identifies Mar26 as a determinant in cytochrome bc1 complex assembly, showing it connects assembly intermediates to MICOS to coordinate complex III maturation at crista junctions.

This study shows that TbPam16 and TbPam18 in Trypanosoma brucei regulate maxicircle replication in mitochondria through a novel regulatory circuit involving MaRF11 and proteasomal control.

The paper identifies TbTim15 as an essential subunit of the trypanosome TIM complex, showing it mediates import of both presequence-containing and mitochondrial carrier proteins.

The paper identifies 28 novel glycosomal membrane proteins in trypanosomes, validates four new ones, and identifies PEX15 as a key protein essential for glycosome biogenesis and parasite survival.