Xiao-Chen Wang

This study shows GGPP promotes hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4, and inhibiting GGPP synthase reduces these effects.

AtaCNV detects high-resolution copy number variations from scATAC-seq data, effectively distinguishing malignant from non-malignant cells and identifying subclones in cancer samples.

scFusion detects gene fusions in single-cell RNA sequencing data with high sensitivity and low false discovery rate, successfully identifying fusions missed by bulk methods.

scRMD imputes dropout values in scRNA-seq data using robust matrix decomposition, improving downstream analysis accuracy.