John Dozier Gordan

This study shows that PI3K mutations contribute to resistance to KRAS inhibitors in colorectal cancer and that combining RAS and PI3K inhibition overcomes this resistance.

This study develops small molecules that activate the tumor suppressor kinase LKB1 and shows their therapeutic benefits in cancer cell lines.

The paper identifies a 30-gene transcriptional signature that detects LKB1 functional loss in tumors, revealing a larger patient population than genomic loss alone.

This study shows that human GM-CSF and IL-3 expression in humanized mice increases immune cell infiltration in HCC tumors, improving the model's resemblance to human disease.