Author

Alexandre B. Leitão

Champalimaud FoundationORCID 0000-0001-9004-1831Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:Drosophila· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

Francis M. JigginsiD· 2 shared Shuyu Olivia ZhouiD· 2 shared Amina Irfan· 1 shared Bart DeplanckeiD· 1 shared Jonathan P. DayiD· 1 shared Ramesh ArunkumariD· 1 shared Shuai Dominique DingiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

Francis M. JigginsORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 12, 2024

A humoral immune response to parasitoid wasps in Drosophila is regulated by JAK/STAT, NF-κB and GATA

Shuyu Olivia Zhou, Jonathan P. Day, Bart Deplancke…·Francis M. Jiggins

This study identifies JAK/STAT, GATA, and NF-κB pathways as regulators of lectin-24A, a gene involved in Drosophila's humoral immune response to parasitoid wasps.

1 citation

Drosophilabulk RNA-seq

𝕏 PostBluesky

Evolutionary BiologyPLoS PathogensPeer-reviewedJan 11, 2024

The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure

Shuyu Olivia Zhou, Ramesh Arunkumar, Amina Irfan…·Francis M. Jiggins

This study shows that Drosophila populations under high parasite pressure evolved constitutive humoral immunity and enhanced induced immune responses, with Upd3 and JAK/STAT signaling playing key roles.

9 citations

Drosophilabulk RNA-seq

𝕏 PostBluesky