Pornpimol Charoentong

The paper introduces optiPRM, a targeted LC-MS workflow that enhances sensitivity for detecting mutation-derived neoepitopes from limited tumor samples.

quanTIseq estimates absolute fractions of ten immune cell types from bulk RNA-seq; across TCGA, CXCL9/CXCR3 expression, not mutational load, tracks CD8+ T cell infiltration.

This study shows that neutral evolution dominates tumor shaping in a mouse CRC model, and PD-1/PD-L1 blockade enhances immunoediting and tumor homogeneity.

Immunogenomic profiling of 8243 TCGA samples across 20 solid cancers yields an immune atlas and a random-forest-derived immunophenoscore stratifying melanoma responders to checkpoint blockade.