Jens C. Schmidt

The paper shows that a dynamic RNA hub formed by nascent switch region transcripts facilitates AID recruitment to the IgH locus, driving class switch recombination.

This study uses Cas12a-based knockout screens to identify genetic interactions in the DNA damage response, revealing synthetic lethal and buffering interactions with therapeutic implications.

This study uses extracellular vesicles to deliver IL-10 for macrophage immunomodulation, showing enhanced stability and anti-inflammatory effects compared to free IL-10.

The paper shows Ku prevents aberrant mRNA splicing caused by intronic antisense Alu elements, which affects RNA metabolism and cell viability.

This study identifies distinct shelterin subcomplexes at telomeres, showing TRF1-TIN2-TPP1-POT1 and TRF2-RAP1 occupy non-overlapping sites with different dynamics.

This study shows the PST repeat region of MDC1 is a multivalent chromatin tethering domain with tunable affinity that aids in DNA break tethering during HR and mitosis.

This study identifies poly-ubiquitin as a signal recruiting ATG9A to initiate basal autophagy by mediating autophagy foci assembly.

This study shows that AMPK inhibits phagophore tethering to donor membranes during glucose starvation, slowing autophagosome maturation.

This study identifies MMEJ as the primary DSB repair pathway in mitosis and reveals RHINO's role in directing mutagenic repair to M phase.

This paper characterizes the EPG protein's cellular location, orientation, and dynamics in response to magnetic stimulation, providing insights into magnetoreception mechanisms and magnetogenetics.