Thomas Surrey

The paper demonstrates that CDK5RAP2 can form minimal centrosome-like structures in vitro, recruiting and activating gamma tubulin ring complexes to generate microtubule asters, and identifies key features of centrosome function.

This study shows NuMA acts as a dynein adaptor, stabilizes microtubule minus ends, and facilitates their transport to spindle poles, with γTuRC hindering NuMA binding.