Andrew D. Frugé

This study shows aging reduces proteome plasticity and hypertrophic responses to resistance training in skeletal muscle, but RT partially reverses some aging-related changes.

This study examines if pre-training bone characteristics predict changes in lean tissue mass after resistance training, finding little association.

The paper investigates how resistance exercise and mechanical overload upregulate vimentin in skeletal muscle, linking it to hypertrophy and regeneration.

This study examines how resistance training affects denervated myofibers, senescent cells, and related proteins in middle-aged adults, finding increased muscle-nerve communication proteins but no significant changes in senescent cell content or SASP proteins.

This study investigates the relationship between relative rDNA copy number and resistance training-induced skeletal muscle hypertrophy, finding no significant association.

This study compares DNA methylation and mRNA responses to lower- versus higher-load resistance exercise in trained men, finding similar gene expression and methylation patterns despite differences in exercise intensity.

Resistance training reduces methylation at 63% of mtDNA CpG sites in older males, mimicking a youthful methylome signature and enhancing mitochondrial function.