Bradley A. Ruple

This study shows that transplanting L6 myotube mitochondria reduces hypertrophy and alters proteomic pathways in phenylephrine-treated H9C2 cardiomyocytes.

This study shows aging reduces proteome plasticity and hypertrophic responses to resistance training in skeletal muscle, but RT partially reverses some aging-related changes.

This study compares mitochondrial mRNA and protein responses to high-load and high-volume resistance training in trained men, finding no differences between the two training paradigms.

This study examines how resistance training affects denervated myofibers, senescent cells, and related proteins in middle-aged adults, finding increased muscle-nerve communication proteins but no significant changes in senescent cell content or SASP proteins.

This study develops a novel imaging method (FIM-ID) to show that myofibrillogenesis, not myofibril hypertrophy, drives mechanically induced skeletal muscle growth.

This study examines how resistance training before endurance training affects mitochondrial adaptations, finding that prior resistance training impairs mitochondrial responses to subsequent endurance training.

This study compares DNA methylation and mRNA responses to lower- versus higher-load resistance exercise in trained men, finding similar gene expression and methylation patterns despite differences in exercise intensity.

Resistance training reduces methylation at 63% of mtDNA CpG sites in older males, mimicking a youthful methylome signature and enhancing mitochondrial function.