Joshua M. Peters

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

This study identifies hypoxia as a key driver of immune dysfunction in TB granulomas, correlating with bacterial persistence.

This study shows that high-dose IV BCG vaccination in rhesus macaques enhances airway immune signaling and cellular responses, improving protection against Mtb.

This study uses multi-omics approaches to analyze myeloid cell diversity in TB granulomas and identifies IFN-γ, TGF-β, and time as factors driving macrophage diversity.

The paper develops a recurrent neural network to simulate intracellular signaling by predicting transcription factor activity from ligand concentrations, validated with synthetic and experimental data.