Heike Brötz‐Oesterhelt

The paper investigates imacidin, a cyclic lipopeptide that inhibits the lipid II flippase MurJ, identifying it as a taxa-specific antibacterial agent with potential for precision antibiotics.

This study identifies and characterizes the negamycin biosynthetic gene cluster in Kitasatospora purpeofusca, enabling scalable production through heterologous expression.

The paper shows that GlnA3Mt in M. tuberculosis can glutamylate spermine but is not essential for spermine detoxification, with efflux pumps playing a compensatory role.

The paper investigates microbe-microbe interactions in a synthetic microbial community on Arabidopsis leaves, finding that in vitro pairwise interactions differ from in planta correlation networks, suggesting community-level synergism over competition.

This study uses native metabolomics to identify a family of protease inhibitors from cyanobacteria, revealing their structure and potent biological activity.