Paolo Stincone

The paper investigates how gut commensal strains modulate the growth and virulence of Clostridium perfringens through substrate competition and protein level changes.

This paper discovers NHAP, a fungal metabolite that selectively inhibits Gi-signaling, demonstrating functional blockade in cardiomyocytes without cytotoxicity.

This paper develops a continuous bioreactor to maintain stable nasal microbiomes from swab specimens and synthetic communities, showing long-term stability and S. aureus decolonization.

The paper shows that cooperative siderophore exchange between Rhodotorula kratochvilovae and Pseudomonas species stabilizes the leaf microbiome and protects plants from pathogens.

The paper constructs synthetic nasal communities to study how community composition influences metabolic competition and S. aureus colonization resistance.

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

The paper develops a functional metabolomics framework using synthetic microbial communities and computational analysis to track drug metabolism by gut microbes, identifying metabolites and their correlations with microbial taxa.

The paper introduces a collaborative platform for curating microbial metabolite knowledge to enhance metabolomics data interpretation.

This study shows that Bacillus subtilis uses its extracellular matrix protein TasA to suppress Botrytis cinerea by disrupting fungal structures and delivering antimicrobial compounds, while the fungus responds with adaptive strategies.

This study identifies cyclo(Pro-Tyr) as a metabolite that disrupts eukaryotic cellular membranes by targeting Pma1 ATPase in microdomains, inducing oxidative stress and membrane fluidity changes in fungi and nematodes.

The paper investigates microbe-microbe interactions in a synthetic microbial community on Arabidopsis leaves, finding that in vitro pairwise interactions differ from in planta correlation networks, suggesting community-level synergism over competition.

This study uses native metabolomics to identify a family of protease inhibitors from cyanobacteria, revealing their structure and potent biological activity.