Xosé R. Bustelo

This study identifies oncogenic drivers, expression signatures, and therapeutic vulnerabilities in RHO GTPase pathway genes across multiple cancer types using pan-cancer genomic and transcriptomic data.

The paper investigates the phenotypic impact of individual conserved neuronal microexons and their regulators in zebrafish, finding that microexon deletions have mild effects while Srrm3/4 loss causes severe neurodevelopmental and behavioral changes.

This study shows VAV2 regulates ribosome biogenesis in keratinocytes and oral squamous cell carcinoma, linking it to poor prognosis and identifying RNA polymerase I as a therapeutic target.