Ron Rotkopf

This study investigates how Lgr5+ intestinal stem cells respond to Salmonella infection by initiating cellular remodeling and antimicrobial defense mechanisms.

The paper shows that chromatin tethering to the nuclear envelope prevents clustering and enhances RNAPII accessibility, promoting asymmetric chromatin organization in Drosophila muscle nuclei.

The paper investigates how extrachromosomal DNA (ecDNA) inheritance mechanisms influence cancer evolution through mitotic segregation and micronuclei formation.

The paper compares axon growth programs in Drosophila mushroom body neurons using transcriptomics, identifying the mevalonate pathway as critical for axon regrowth.

The paper investigates the role of pH changes in guanine accumulation and crystallization within zebrafish iridosomes, showing that acidic conditions and V-ATPase activity drive crystal formation.

The paper profiles single-cell RNA sequencing data from sex-shared neurons in C. elegans to reveal molecular dimorphism and sex-biased gene expression patterns.

This study shows that MTCH2 deletion increases energy demand and metabolic imbalance in cells, which inhibits adipocyte differentiation.

This study shows that the Wnt/β-catenin pathway is essential for proprioception by coordinating the development of muscle spindle components through both cell-autonomous and non-cell-autonomous mechanisms.

This study identifies TENT4A as a regulator of DNA-damage tolerance through multiple pathways, with mutations in these pathways linked to endometrial cancer.

This study shows that Robo2 regulates synaptic oxytocin content by affecting actin dynamics in zebrafish.