Meghna Mathur

This study shows PINK1 forms a supercomplex with TOM and TIM23 during mitochondrial stress and is required for tethering TOM to TIM23, which is essential for mitophagy.

The paper develops a flow cytometry pipeline called CelltypeR to annotate and characterize cell types in brain organoids, identifying dopamine neuron subtypes and tracking cell type dynamics over time.

The paper develops a mass spectrometry-based method to measure protein turnover in human induced pluripotent stem cell organoids, comparing results to primary cell cultures and in vivo models.

This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.

This study develops microfabricated disks to scale up midbrain organoid generation, reducing labor and variability while maintaining viability for Parkinson's disease research.