Author

Simone Harrison

University of California, San FranciscoORCID 0000-0001-9581-2471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aashish ManglikiD· 1 shared Alex S. EversiD· 1 shared Carl‐Mikael SuomivuoriiD· 1 shared Debora S. MarksiD· 1 shared Dominik Regele· 1 shared Douglas F. CoveyiD· 1 shared Eduard StefaniD· 1 shared Ishan DeshpandeiD· 1 shared

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2024-2024 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Aashish ManglikORCID

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1 paper

Recent·Most cited

BiochemistryNature Structural & Molecular BiologyPeer-reviewedFeb 7, 2024

GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway

Nick Hoppe, Simone Harrison, Sun‐Hee Hwang…·Aashish Manglik

The paper determines the cryo-EM structure of active GPR161 bound to Gs, revealing sterol binding and its role in ciliary cAMP signaling, while showing that sterol binding is not essential for Hedgehog pathway suppression.

44 citationstop 3%

humanprotein structure

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