ImmunologyCancer Immunology ResearchPeer-reviewed
Enhancing CAR T cell therapy using Fab-Based Constitutively Heterodimeric Cytokine Receptors
Matteo Righi, Isaac Gannon, Mathew P. Robson…·Martin A. Pulè
This paper introduces a dimerization domain from IgG1 antibodies to create engineered cytokine receptors that mimic natural heterodimerization, enhancing CAR T cell therapy efficacy.
15 citations