Raphael G Guzman

The paper shows that CNS macrophage engraftment depends on TRM self-renewal and niche timing, not prolonged vacancy, and identifies a peripheral BAM-like macrophage population in aged human brains.

This paper develops a CAR T cell therapy that secretes a CD47 blocker to enhance anti-EGFRvIII efficacy against glioblastoma by modulating the tumor microenvironment.