Derek C. Chen

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

The paper identifies a disease-associated motor neuron state in a mouse ALS model that precedes cell death and links it to human ALS genetic risk factors.

The paper presents a single-cell multi-omics atlas of human development and uses deep learning to analyze regulatory DNA motifs and their impact on chromatin accessibility and gene expression.

This study shows that Xist ribonucleoprotein complexes drive sex-biased autoimmunity in males, leading to autoimmune pathology and reprogramming of immune cells to resemble female patterns.

The paper analyzes single-nucleus RNA-seq data from human spinal cord neurons, identifies motor neurons as rare, and highlights discrepancies with a prior study due to potential misclassification of cholinergic debris.

The paper maps cell organization and function across human intestine regions using single nuclear RNA and open chromatin assays, revealing distinct cell neighborhoods and regulatory differences.

The paper uses single-cell data to show a continuum of cell state and composition changes from polyps to colorectal cancer, identifying stem-like cells and regulatory markers.