Author

Wengang Zhang

Frederick National Laboratory for Cancer ResearchORCID 0000-0001-9653-6966Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

Hyunbum JangiD· 2 shared Ruth NussinoviD· 2 shared Yonglan LiuiD· 2 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

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2 shared papersCancer Biology

Hyunbum JangORCID

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2 papers

Recent·Most cited

Cancer BiologyJournal of Chemical Information and ModelingPeer-reviewedJan 10, 2025

mTOR variants activation discovers PI3K-like cryptic pocket, expanding allosteric, mutant-selective inhibitor designs

Yonglan Liu, Wengang Zhang, Hyunbum Jang, Ruth Nussinov

The paper identifies a cryptic pocket in mTOR oncogenic variants through molecular dynamics simulations and suggests designing PI3K-like inhibitors to target this pocket for therapeutic benefit.

11 citations

humanproteomics

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Molecular BiologybioRxivPreprintAug 16, 2023

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2

Wengang Zhang, Yonglan Liu, Hyunbum Jang, Ruth Nussinov

The paper investigates why cyclin-D/CDK4 drives the longer G1 phase while cyclin-E/CDK2 regulates the short G1/S transition, proposing slower activation for cyclin-D/CDK4 and faster for cyclin-E/CDK2, with implications for CDK4 inhibitor design.

10 citations

statistical model

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