Author

William Nathaniel Brennen

Johns Hopkins UniversityORCID 0000-0001-9807-7433Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Timothy E. G. KruegeriD· 2 shared Adel MandliD· 1 shared Angelo Michael De MarzoiD· 1 shared Brian P. HanrattyiD· 1 shared Brian Wesley SimonsiD· 1 shared Bulouere Abel· 1 shared D. Marc Rosen· 1 shared Daniel A.C. Fisher· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Timothy E. G. KruegerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 14, 2025

Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer

Kenji Zennami, Mindy Kim Graham, Shireen Chikara…·Shawn E. Lupold

This study shows that loss of miR-21 in MYC-driven prostate cancer reduces tumor progression by affecting cell-type-specific gene regulation and immune infiltration.

1 citation

mousescRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJan 17, 2024

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

Sumer Jasmine, Rajendra Kumar, Sunghyun Kim…·William Nathaniel Brennen

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

7 citations

humanbulk RNA-seq

𝕏 PostBluesky

BioinformaticsNature CommunicationsPeer-reviewedMar 23, 2023

IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry

Peng Lu, Karolyn A. Oetjen, Diane E. Bender…·Daniel L.J. Thorek

IMC-Denoise improves Imaging Mass Cytometry image quality by reducing noise and artifacts, enhancing downstream analysis.

68 citationstop 2%

humanimaging

𝕏 PostBluesky