Pawel J. Sikorski

This study identifies RNA length as a species-specific threshold for innate immune recognition, showing that different RNA sensors (RIG-I and MDA5) determine antiviral sensing across human, duck, and chicken cells.

The paper shows that effective dsRNA recognition can occur without inflammation, with distinct pathways activated by different RNA features.

This paper introduces a modified mRNA cap analog, AvantCap, which improves mRNA purification and translational efficiency in vitro and in vivo.