Tina Fink

This paper develops a pharmacologically controlled system for regulating CAR T cell function using estrogen receptor-based degron domains and FDA-approved compounds.

The paper introduces a system to regulate protein function and create Boolean logic gates using coiled-coil dimers in protein loops, demonstrated on ten diverse proteins.

The paper introduces two genetically encoded secretion systems that enable fast, chemically regulated protein secretion by cleaving ER retention signals, bypassing the need for transcription and translation.