Christopher Maffeo

This study uses DNA-origami rings to investigate FG-Nup interactions and their impact on NPC function, revealing how sequence and post-translational modifications affect protein behavior.

The paper demonstrates that rotating DNA duplexes can transport water and ions through a nanoscale pore, with cation transport driven by electrostatic interactions and potential applications in ion separation.

This paper introduces DNA-Lipid Nanodiscs (DLNs) with a PEG interface to study membrane proteins and lipid bilayers, showing effective shielding of hydrophobic mismatch through PEG-lipid interactions.

This paper introduces a nanoinjection platform using nanopipettes to deliver macromolecules into cells with single molecule resolution, showing phenotypic changes and enhanced detection through macromolecular crowding.

The paper designs DNA nanochannels that allow small molecules to diffuse through micron-length channels, demonstrating controlled transport between compartments.

The paper introduces MrDNA, a multi-resolution simulation framework that predicts DNA nanostructure structures and dynamics with high accuracy, comparable to cryo-EM, in under 30 minutes.