James E. Korkola

This study identifies SASP factors that drive tumorigenesis in breast and lung cancer cells using a microarray platform and validates their role in growth and survival.

This study identifies SNO-COX-2 as a biomarker for mesenchymal phenotypes in breast cancer, showing its microenvironmental regulation and association with invasive growth.

The paper presents a LINCS Microenvironment perturbation dataset cataloging transcriptional, proteomic, epigenomic, and phenotypic responses of MCF10A cells to six ligands, enabling integrative analysis of molecular and phenotypic changes.

The paper develops a method to remove technical artifacts from high-throughput imaging assays using systematic replication, improving biological signal clarity.

The paper investigates how preprocessing transformations improve the discovery of biological and technical effects in microenvironment microarray data.

This study investigates factors affecting the reproducibility of in vitro drug-response assays across multiple centers, identifying context-sensitive factors that impact results.

The paper investigates context-specificity in signaling networks using phosphoprotein profiling in breast cancer cell lines under various stimuli and kinase inhibition.