Bert A. ‘t Hart

This study uses human post-mortem brain slice cultures to investigate focal and subtle myelin damage in multiple sclerosis, showing the model's utility for studying human myelin pathology.

This study uses third harmonic generation microscopy to image myelin in live human brain tissue, revealing its utility in detecting subtle myelin changes in neurological conditions.

The paper assesses axonal mitochondrial content and complex IV activity in multiple experimental disease models of MS, finding that increased mitochondrial content does not always correlate with increased COX activity, and that COX activity inversely correlates with axonal injury.

This paper shows that targeting MOG to skin macrophages via a fusion protein prevents EAE in macaques by inducing TGFβ-mediated peripheral tolerance.