Genetic & Genomic MedicinemedRxivPreprint
Comparison of PU.1 genomic binding across immune cells reveals cell type-specific roles in autoimmune disease
David A. Lewis, Molly Shook, Lucinda P. Lawson…·Leah Claire Kottyan
Author
David F. Smith
Cincinnati Children's Hospital Medical CenterORCID 0000-0002-0048-4012Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2018-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 33 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- GenomicsSLEEPPeer-reviewed
Machine learning approaches to identify sleep genes
Yin Yeng Lee, Mehari Endale, Gang Wu…·John B. Hogenesch
This study uses machine learning to predict sleep-related genes from genomic data and validates the NF-κB pathway's role in sleep duration in mice.
13 citations - GeneticsbioRxivPreprint
High-resolution promoter interaction analysis implicates genes involved in the activation of Type 3 Innate Lymphoid Cells in autoimmune disease risk
Valeriya Malysheva, Helen F. Ray-Jones, Nora Lakes…·Mikhail Spivakov
The paper maps promoter interactions in human ILC3s using PCHi-C and links GWAS risk variants to target genes, identifying new autoimmune disease risk genes.
- Genetic & Genomic MedicinemedRxivPreprint
Detailed Clinical and Functional Studies of New MTOR Variants in Smith-Kingsmore Syndrome Reveal Deficits of Circadian and Sleep Homeostasis
Andrew C. Liu, Yang Shen, Destino Roman…·Carlos Enrique Prada
This study identifies new MTOR variants in Smith-Kingsmore Syndrome, reveals circadian and sleep deficits, and shows rapamycin treatment can improve symptoms.
3 citations - Systems BiologyGenome MedicinePeer-reviewed
A single-sample circadian biomarker that performs across populations and platforms
Gang Wu, Marc D. Ruben, Lauren J. Francey…·John B. Hogenesch
The paper develops a 12-gene circadian biomarker from epidermal samples that accurately estimates circadian phase across body sites, ages, sexes, and platforms.
50 citations - Systems BiologyProceedings of the National Academy of SciencesPeer-reviewed
Population level rhythms in human skin: implications for circadian medicine
Gang Wu, Marc D. Ruben, Robert E. Schmidt…·John B. Hogenesch
The paper identifies robust circadian rhythms in human skin at the population level and develops single-sample biomarkers for circadian phase.
121 citationstop 2% - BioinformaticsbioRxivPreprint
A population-based human enCYCLOPedia for circadian medicine
Marc D. Ruben, Gang Wu, David F. Smith…·John B. Hogenesch
The paper identifies rhythmic gene expression across human tissues using computational methods and highlights implications for circadian medicine in cardiovascular disease.
7 citations