Benoı̂t Viollet

This study shows that SIX1 regulates muscle fiber hypertrophy by modulating metabolism and fiber type transitions in response to mechanical overload.

This paper shows that MK-8722, a direct AMPK activator, inhibits SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy, and enhancing type I IFN response, even when applied post-exposure.

This study shows that activating AMPK reduces MIF release from macrophages under low glucose conditions by inhibiting NFB signaling.

This study shows that AMPK is necessary for exercise-induced liver adaptations in glycogen and lipid metabolism in mice.

This study shows Aβ42 oligomers cause synaptic loss by activating CAMKK2-AMPK, which coordinates mitochondrial fission and mitophagy in neurons.

This study shows that prolactin-induced AMPK regulates mammary alveologenesis and lactogenesis by modulating STAT5 signaling in mice.

The paper identifies the AMPK-TFEB-FLCN axis as a regulator of cellular and metabolic homeostasis through gene expression and functional studies in mice and zebrafish.