Author

Zhi Hong Wen

Marshfield Clinic Research FoundationORCID 0000-0002-0170-622XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Siegfried Janz· 2 shared Yidan Wang· 2 shared Adam M. Bissonnette· 1 shared Adedayo A. OnitiloiD· 1 shared Ansul Sharma· 1 shared Benita S. KatzenellenbogeniD· 1 shared Deepak ParashariD· 1 shared Gene E. Ananiev· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Siegfried Janz

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 27, 2024

Inhibition of FOXM1 synergizes with BCL2 inhibitor Venetoclax in killing non-t(11;14) multiple myeloma cells via repressing MYC pathway

Zhi Hong Wen, Siegfried Janz, Yidan Wang…·Adedayo A. Onitilo

This paper shows that combining FOXM1 inhibitor NB73 with Venetoclax kills non-t(11;14) multiple myeloma cells by blocking the MYC pathway.

DOI 10.1101/2024.09.27.613548

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 26, 2023

Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways

Yidan Wang, Todd G. Kroll, Linhui Hao…·Zhi Hong Wen

This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.

DOI 10.1101/2023.12.26.573366

humanbulk RNA-seq

𝕏 PostBluesky