Isabelle K. Gorham

This study shows that acute exposure to cell-free mitochondrial DNA in pregnant rats causes aortic endothelial dysfunction and organ-specific inflammation, with partial TLR9 involvement.

This study shows that extracellular mitochondrial DNA induces sex-specific placental inflammation in rats, mediated partially by TLR9, with lasting effects on antioxidant enzymes and stillbirth risk.

This study shows that gestational chronic intermittent hypoxia increases maternal inflammation, alters EV characteristics, and disrupts placental stress responses in rats without affecting fetal growth.

This study shows oxidative stress induces mtDNA release and non-apoptotic cell death in BeWo trophoblast cells, with implications for placental pathology and ccf-mtDNA biomarkers.