Don C. Lamb

This paper develops fluorescently labeled GagPol variants for live-cell imaging of HIV-1 assembly, enabling single-cell analysis of Gag and GagPol interactions and dynamics.

This study uses smFRET to analyze conformational dynamics of FicD's TPR motifs, showing equilibrium between TPR-in and TPR-out states influenced by ATP and BiP.

This paper introduces a triple-labeling strategy for single molecule FRET to study conformational changes in GPCRs, revealing a previously unknown intermediate state.

The paper identifies DPPA3 as a driver of genome-wide passive DNA demethylation in mammals, showing it can bypass TET protein requirements and function across species.