Ryan O. Schenck

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

This paper develops computational frameworks to design personalized multi-strike therapies for ovarian cancer that reduce toxicity while enhancing tumor extinction.

The paper introduces rapidly oscillating molecular clocks to quantify human stem cell dynamics and finds differences in stem cell replacement rates between small intestine and colon, as well as effects of germline mutations.

NeoPredPipe predicts and assesses neoantigen recognition potential from tumor variants in single and multi-region samples, providing insights into neoantigen burden and tumor heterogeneity.

The paper introduces the Hybrid Automata Library (HAL), a Java platform for building hybrid models in mathematical oncology, with real-time visualization and modular components.