Author

Duminda S. Ranasinghe

ORCID 0000-0002-0318-2888Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:diffusion model· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Hok Hei TamiD· 2 shared Changchang LiuiD· 1 shared Daniel Spitz· 1 shared Darren Jason HsuiD· 1 shared Emine KüçükbenliiD· 1 shared Jayant Bhambhani· 1 shared Matthew Parks· 1 shared Nathan E SandersiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioinformatics

Hok Hei TamORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintOct 10, 2025

Blind Virtual Screening at Scale: A Scalable End-to-End Pipeline for Blind Docking and Affinity Prediction

Matthew Parks, Xin Yu, Yuxing Peng…·Hok Hei Tam

This paper presents a scalable end-to-end pipeline for blind virtual screening using DiffDock and UniDock Vina, achieving high screening performance with minimal pose generation.

DOI 10.1101/2025.10.10.681617

diffusion modeldrug response / drug discovery

𝕏 PostBluesky

BiophysicsbioRxivPreprintJan 16, 2024

ComboPath: An ML system for predicting drug combination effects with superior model specification

Duminda S. Ranasinghe, Nathan E Sanders, Hok Hei Tam…·Daniel Spitz

ComboPath predicts interpretable dose response surfaces for drug combinations using biophysically-motivated modeling, improving model specification and accuracy on combinatoric screening data.

2 citations

machine learning (classical)drug response / drug discovery

𝕏 PostBluesky