Isao Naguro

This study shows that proteasome activity inactivates ASK3 by degrading ASK1, linking proteasome function to cell survival under hyperosmotic stress.

The paper introduces ContactBlot, a microfluidic method to measure ERK signaling in HeLa cells under different contact states, finding reduced ERK activity in contact versus isolated cells.

The paper shows that zinc deficiency impairs KAT7-dependent H3K14ac at enhancers, upregulating ZIP10 and lipid droplet genes in mice, linking zinc homeostasis to epigenetic regulation.