Daniel Bsteh

This paper evaluates circulating microbial DNA as a cancer biomarker, finding that observed patterns are largely artifacts of sequencing and analysis methods rather than biological signals.

The paper identifies PDS5A as a cohesin regulator linking Polycomb silencing and 3D genome organization, showing that its loss disrupts cohesin activity and Polycomb loops without affecting repressive chromatin marks.

This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.