Friederike Zunke

This study shows that FICD-mediated AMPylation contributes to Parkinson's disease by promoting α-synuclein aggregation and protein dyshomeostasis in dopaminergic neurons.

This study shows TNF-α disrupts the malate-aspartate shuttle in iPSC-derived enteric neural cells from PD patients, causing metabolic shifts and mitochondrial dysfunction, which can be reversed by targeting glutamate metabolism.

This study shows that linear ubiquitination at damaged lysosomes activates NF-κB and promotes cell survival through lysophagy.

The paper develops a tagless LysoIP method to isolate lysosomes from clinical samples and human cell lines, revealing glycerophosphodiesters as potential biomarkers for lysosomal storage disorders.

The paper identifies key residues in SARS-CoV-2 variants that affect ACE2 binding using molecular dynamics simulations and energy decomposition.