Tianyi Yang

The paper identifies frustrated residues in GPCR:G protein interfaces and engineered degrader complexes, showing higher frustration in engineered interfaces.

This study uses protein frustration analysis to identify key residues distinguishing strong from weak BRD4-Cereblon degraders.

This study shows that lipids like PIP2 and GM3 modulate the conformation of ICL3 in beta-2AR, affecting G protein coupling through membrane tilting and allosteric effects.