Author

Clive J. Hoggart

Icahn School of Medicine at Mount SinaiORCID 0000-0002-0482-0052Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 1 Research Focus:polygenic risk· 1 Approach:simulation· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam Gordon· 1 shared Amit V. KheraiD· 1 shared Anil P. S. OriiD· 1 shared Atlas KhaniD· 1 shared Bahram NamjouiD· 1 shared C. KachulisiD· 1 shared Candace Guiducci· 1 shared Carla Giner-DelgadoiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Adam Gordon

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 12, 2024

Stabilising selection enriches the tails of complex traits with rare alleles of large effect

Anil P. S. Ori, Carla Giner-Delgado, Clive J. Hoggart, Paul F. O’Reilly

This study shows that stabilising selection enriches the tails of complex traits with rare alleles of large effect, which may have significant clinical implications.

2 citations

simulation

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Genetic & Genomic MedicinemedRxivPreprintMay 25, 2023

Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations

Niall J. Lennon, Leah Claire Kottyan, C. Kachulis…·Eimear E. Kenny

The paper selects and validates ten polygenic risk scores for clinical use in diverse populations, focusing on chronic diseases and addressing disparities in predictive performance.

7 citations

humanwhole-genome sequencing

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