Dalmira Hubrich

The paper improves variant effect prediction in intrinsically disordered regions by combining sequence analysis, AlphaFold, and experiments to annotate protein interactions and predict deleterious variants.

The paper evaluates AlphaFold-Multimer for predicting protein interaction interfaces using short linear motifs and validates some predictions experimentally.

This study shows that single-mutant EGF ligands alter EGFR dimer stability and signaling, supporting biased signaling theory.