Alexandra N. Melloni

The paper shows lipidated ApoE is closely located to Aβ aggregates in human Alzheimer's brains, suggesting a role in plaque formation.

The paper identifies rare bioactive tau oligomers in Alzheimer's brain that can induce templated misfolding and fibril formation, distinguishing them from non-bioactive oligomers.

This study identifies proteomic changes in Alzheimer's disease, revealing decreased 20S proteasome levels and altered ubiquitin system enzymes contributing to protein accumulation.

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.