Ikuo Shoji

The paper identifies a leucine-rich motif in NTCP essential for KIF4-mediated trafficking and HBV/HDV infection, revealing a conserved cargo recognition mechanism shared with integrin β1.

This study shows HCV infection causes LATS1 degradation via ubiquitin-mediated proteasomal pathway, inactivating the Hippo pathway and increasing CYR61 and CTGF gene transcription.

This study identifies that HCV NS3/4A protease cleaves SPG20, disrupting Itch-mediated degradation of ADRP and promoting lipid droplet formation in infected cells.

This study identifies S169, an RXR agonist, as an inhibitor of HBV/HDV entry by disrupting KIF4-dependent NTCP trafficking in human hepatocytes.