Lichun He

This study shows chaperones modulate enzyme activity in native states, expanding their role beyond protein folding.

The paper identifies two co-factors that enhance Pfu DNA polymerase performance using NMR-based hot spot residue screening without prior structural data.

This paper identifies functional hotspots in large enzymes using a hybrid NMR-computational approach, enabling efficient directed evolution with targeted mutagenesis.

This study demonstrates how the oligopeptide (FK)4 enables the determination of absolute stereochemistry of chiral compounds using NMR spectroscopy by combining alignment medium and chiral differentiating properties.