Cancer BiologybioRxivPreprint
Complementary modes of resistance to EGFR TKI in lung adenocarcinoma through MAPK activation and cellular plasticity
Matthew Zatzman, Àlvaro Quintanal-Villalonga, Sohrab Salehi…·Helena Alexandra Yu
This study identifies MAPK activation and cellular plasticity as complementary resistance mechanisms to EGFR TKI in lung adenocarcinoma using single-nuclei RNA sequencing and clinical data.